USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: ARRB1_HUMAN USC-OGP 2-DE database:  ARRB1_HUMAN ARRB1_HUMAN General information about the entry View entry in simple text format Entry name ARRB1_HUMAN Primary accession number P49407 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Beta-arrestin-1; AltName: Full=Arrestin beta-1;. Gene name Name=ARRB1 Synonyms=ARR1 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0341: pI=5.90; Mw=55343 SPOT OGP-0352: pI=5.86; Mw=52096 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0657: pI=5.83; Mw=54059 SPOT OGP-0661: pI=5.86; Mw=53126 Cross-references UniProtKB/Swiss-Prot P49407; ARRB1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ARRB1_HUMAN Primary accession number P49407 Secondary accession number(s) B6V9G8 O75625 O75630 Q2PP20 Q9BTK8 Sequence was last modified on  March 5, 2002 (version 2) Annotations were last modified on  March 15, 2017 (version 165) Name and origin of the protein Description RecName: Full=Beta-arrestin-1; AltName: Full=Arrestin beta-1; Gene name Name=ARRB1 Synonyms=ARR1 Encoded on Name=ARRB1; Synonyms=ARR1 Keywords 3D-structure; Alternative splicing; Cell membrane; Cell projection; Coated pit; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Membrane; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Signal transduction inhibitor; Transcription; Transcription regulation; Transport; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL L04685; AAA35559.1; -; mRNA EMBL L04685; AAA35558.1; -; mRNA EMBL AF084040; AAC33295.1; -; mRNA EMBL AF084940; AAC34123.1; -; mRNA EMBL DQ314865; ABC40724.1; -; Genomic_DNA EMBL FJ348262; ACI96306.1; -; mRNA EMBL CH471076; EAW74962.1; -; Genomic_DNA EMBL BC003636; AAH03636.1; -; mRNA CCDS CCDS31640.1; -. [P49407-2]; . CCDS CCDS44684.1; -. [P49407-1]; . PIR B46682; B46682; . RefSeq NP_004032.2; NM_004041.4. [P49407-1]; . RefSeq NP_064647.1; NM_020251.3. [P49407-2]; . UniGene Hs.503284; -; . UniGene Hs.625320; -; . PDB 2IV8; X-ray; 2.80 A; P/Q=383-402 PDBsum 2IV8; -; . ProteinModelPortal P49407; -; . SMR P49407; -; . BioGrid 106901; 255; . DIP DIP-29979N; -; . IntAct P49407; 212; . MINT MINT-128176; -; . STRING 9606.ENSP00000409581; -; . BindingDB P49407; -; . ChEMBL CHEMBL1795088; -; . iPTMnet P49407; -; . PhosphoSitePlus P49407; -; . BioMuta ARRB1; -; . DMDM 20141238; -; . OGP P49407; -; . EPD P49407; -; . MaxQB P49407; -; . PaxDb P49407; -; . PeptideAtlas P49407; -; . PRIDE P49407; -; . DNASU 408; -; . Ensembl ENST00000360025; ENSP00000353124; ENSG00000137486. [P49407-2]; . Ensembl ENST00000420843; ENSP00000409581; ENSG00000137486. [P49407-1]; . GeneID 408; -; . KEGG hsa:408; -; . UCSC uc001owe.3; human. [P49407-1]; . CTD 408; -; . DisGeNET 408; -; . GeneCards ARRB1; -; . HGNC HGNC:711; ARRB1; . HPA CAB003763; -; . HPA HPA049318; -; . MIM 107940; gene; . neXtProt NX_P49407; -; . OpenTargets ENSG00000137486; -; . PharmGKB PA59; -; . eggNOG KOG3865; Eukaryota; . eggNOG ENOG410XR0F; LUCA; . GeneTree ENSGT00390000013152; -; . HOGENOM HOG000231319; -; . HOVERGEN HBG002399; -; . InParanoid P49407; -; . KO K04439; -; . OMA LMHPKPL; -; . OrthoDB EOG091G05M2; -; . PhylomeDB P49407; -; . TreeFam TF314260; -; . Reactome R-HSA-2122948; Activated NOTCH1 Transmits Signal to the Nucleus; . Reactome R-HSA-418555; G alpha (s) signalling events; . Reactome R-HSA-432720; Lysosome Vesicle Biogenesis; . Reactome R-HSA-432722; Golgi Associated Vesicle Biogenesis; . Reactome R-HSA-456926; Thrombin signalling through proteinase activated receptors (PARs); . Reactome R-HSA-5635838; Activation of SMO; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . Reactome R-HSA-8856825; Cargo recognition for clathrin-mediated endocytosis; . Reactome R-HSA-8856828; Clathrin-mediated endocytosis; . SignaLink P49407; -; . SIGNOR P49407; -; . ChiTaRS ARRB1; human; . EvolutionaryTrace P49407; -; . GeneWiki Arrestin_beta_1; -; . GenomeRNAi 408; -; . PRO PR:P49407; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000137486; -; . CleanEx HS_ARRB1; -; . ExpressionAtlas P49407; baseline and differential; . Genevisible P49407; HS; . GO GO:0016323; C:basolateral plasma membrane; IEA:Ensembl; . GO GO:0000785; C:chromatin; IDA:BHF-UCL; . GO GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB; . GO GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0043197; C:dendritic spine; IEA:Ensembl; . GO GO:0000139; C:Golgi membrane; TAS:Reactome; . GO GO:0005765; C:lysosomal membrane; TAS:Reactome; . GO GO:0016604; C:nuclear body; IDA:HPA; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; TAS:ProtInc; . GO GO:0014069; C:postsynaptic density; IEA:Ensembl; . GO GO:0045211; C:postsynaptic membrane; IEA:Ensembl; . GO GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell; . GO GO:0031701; F:angiotensin receptor binding; IPI:UniProtKB; . GO GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl; . GO GO:0004857; F:enzyme inhibitor activity; TAS:ProtInc; . GO GO:0005096; F:GTPase activator activity; IMP:UniProtKB; . GO GO:0005159; F:insulin-like growth factor receptor binding; IPI:UniProtKB; . GO GO:0008134; F:transcription factor binding; IPI:UniProtKB; . GO GO:0044212; F:transcription regulatory region DNA binding; IMP:BHF-UCL; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB; . GO GO:0000187; P:activation of MAPK activity; IEA:Ensembl; . GO GO:0042699; P:follicle-stimulating hormone signaling pathway; IEA:Ensembl; . GO GO:0002031; P:G-protein coupled receptor internalization; IMP:UniProtKB; . GO GO:0061024; P:membrane organization; TAS:Reactome; . GO GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl; . GO GO:0034260; P:negative regulation of GTPase activity; IEA:Ensembl; . GO GO:0032715; P:negative regulation of interleukin-6 production; IDA:UniProtKB; . GO GO:0032717; P:negative regulation of interleukin-8 production; IDA:UniProtKB; . GO GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB; . GO GO:0031397; P:negative regulation of protein ubiquitination; IDA:UniProtKB; . GO GO:0007602; P:phototransduction; IEA:Ensembl; . GO GO:0030168; P:platelet activation; TAS:Reactome; . GO GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl; . GO GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB; . GO GO:0035066; P:positive regulation of histone acetylation; IMP:BHF-UCL; . GO GO:0090240; P:positive regulation of histone H4 acetylation; IMP:UniProtKB; . GO GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl; . GO GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl; . GO GO:0032092; P:positive regulation of protein binding; IEA:Ensembl; . GO GO:0001934; P:positive regulation of protein phosphorylation; IMP:UniProtKB; . GO GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl; . GO GO:0002092; P:positive regulation of receptor internalization; IMP:UniProtKB; . GO GO:0035025; P:positive regulation of Rho protein signal transduction; IMP:UniProtKB; . GO GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; IEA:Ensembl; . GO GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IMP:UniProtKB; . GO GO:0015031; P:protein transport; IEA:UniProtKB-KW; . GO GO:0016567; P:protein ubiquitination; IMP:UniProtKB; . GO GO:0042493; P:response to drug; IEA:Ensembl; . GO GO:0043149; P:stress fiber assembly; IMP:UniProtKB; . GO GO:0006366; P:transcription from RNA polymerase II promoter; IMP:UniProtKB; . Gene3D 2.60.40.640; -; 1; . Gene3D 2.60.40.840; -; 1; . InterPro IPR000698; Arrestin; . InterPro IPR011021; Arrestin-like_N; . InterPro IPR014752; Arrestin_C; . InterPro IPR011022; Arrestin_C-like; . InterPro IPR017864; Arrestin_CS; . InterPro IPR014753; Arrestin_N; . InterPro IPR014756; Ig_E-set; . PANTHER PTHR11792; PTHR11792; 1; . Pfam PF02752; Arrestin_C; 1; . Pfam PF00339; Arrestin_N; 1; . PRINTS PR00309; ARRESTIN; . SMART SM01017; Arrestin_C; 1; . SUPFAM SSF81296; SSF81296; 2; . PROSITE PS00295; ARRESTINS; 1; .

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